Hebei ShengYang Biological Technology Co. Ltd(expird)
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CAS NO.137-58-6
lidocaine is a local anesthetic, also known as xylocaine, in recent years it has been replaced procaine, widely used in local infiltration anesthesia in cosmetic plastic surgery, it can block the nerve excitability and conduction by inhibiting the sodium channels of nerve cell membrane. the fat soluble and protein binding rate of lidocaine is higher than procaine, its cell penetrating ability is strong, fast onset, long duration of action, the interaction strength is 4 times of procaine.
lidocaine is used in infiltration anesthesia, epidural anesthesia, topical anesthesia (including thoracoscopy or abdominal surgery for mucosal anesthesia) and nerve block. in order to extend the time of anesthesia, reduce the poisoning of lidocaine and other side effects, can be added in the anesthetic epinephrine.
lidocaine can also be used for the treatment of ventricular premature beat after acute myocardial infarction, ventricular tachycardia, digitalis poisoning, cardiac surgery and cardiac catheterization-induced ventricular arrhythmias, including ventricular premature beats, ventricular tachycardia and ventricular fibrillation. lidocaine is also used for duration status of epilepsy which other anti-seizure drugs are not effective, as well as local or spinal anesthesia. but it is usually ineffective for supraventricular arrhythmias.
| cas |
137-58-6 |
| synonyms |
2-(diethylamino)-2',6'-acetoxylidide;2-(diethylamino)-2,6'-acetoxylidide;2-(diethylamino)-n-(2,6-dimethylphenyl)-acetamid;2',6'-acetoxylidide, 2-(diethylamino)-;6'-acetoxylidide,2-(diethylamino)-2;acetamide, 2-(diethylamino)-n-(2,6-dimethylphenyl)-;acetamide,2-(diethylamino)-n-(2,6-dimethylphenyl)-;a-diethylamino-2,6-acetoxylidide |
| mf |
c14h22n2o |
| mw |
234.34 |
| einecs |
205-302-8 |
| melting point |
66-69°c |
| storage temp |
store at rt |
| solubility ethanol |
4 mg/ml |
| certification |
gmp, iso 9001, usp, bp |
| standard |
pharma grade |
| usage |
topically used to relieve itching, burning and pain from skin inflammations, injected as a dental anesthetic, or as a local anesthetic for minor surgery. |
| packing |
discreet packing ways as your requirement, 100% go through |
| storage |
store in cool and dry area and keep away from direct sunlight |
specification
|
appearance |
|
white or off white crystal powder |
|
complies |
|
solubility |
|
very soluble in methanol and ethanol. |
|
complies |
|
identification |
|
|
|
|
|
absorbance |
|
nmt0.02 at 420nm(1/20 in methanol) |
|
complies |
|
water |
|
nmt 2.00% |
|
1.02% |
|
residue on ignition |
|
nmt 0.1% |
|
0.05% |
|
heavy metals |
|
nmt 0.001% |
|
complies |
|
total impurities |
|
nmt 0.3% |
|
0.28% |
|
assay |
|
nlt 98.0% and nmt 102.0% |
|
99.0% |
|
(hplc) |
|
calculated on the anhydrous basis |
|
|
|
residual solvents by gc |
|
|
|
|
|
hexanes |
|
nmt 0.029% |
|
0.0058% |
|
ethylacetate |
|
nmt 0.50% |
|
0.1321% |
|
methylenechloride |
|
nmt 0.06% |
|
0.0036% |
|
xylene(mixture) |
|
nmt 0.216% |
|
0.0051% |
conclusion:it complies with all the requirements of usp 31.
function
topical lidocaine has been shown in some patients to relieve the pain of postherpetic neuralgia (a complication of shingles), though there is not enough study evidence to recommend it as a first-line treatment. iv lidocaine also has uses as a temporary fix for tinnitus. although not completely curing the disorder, it has been shown to reduce the effects by around two thirds. lidocaine hydrochloride injection administered intravenously or intramuscularly, is specifically indicated in the acute management of ventricular arrhythmias such as those occurring in relation to acute myocardial infarction, or during cardiac manipulation, such as cardiac surgery.
packaging and delivery
package: 25kg/drum or as your request.
storage situation: stored in a cool and dry well-closed container. keep away from moisture and strong light/heat.
shelf life: two years when properly stored.
delivery: within two weeks after receiving your prepayment.
Q1: Can i get some samples
A: Yes, we can supply the free sample, but the shipping cost be paid by our customers.
Q2: How to start orders or make payments
A: Proforma invoice will be sent first after confirmation of order, enclosed our bank information. Payment by T/T, , Paypal or Escrow.
Q3: How to confirm the Product Quality before placing orders
A:You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.
Q4:What's your MOQ
A:Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.
Q5: How about delivery lead time
A:Delivery lead time: About 3-5 days after payment confirmed. (Chinese holiday not included)
Q6:Is it OK to print my logo on package
A:Sure.Please inform and offer your Logo formally before production.