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CAS NO.130-95-0
Introduction of Quinine HCL
Quinine HCL is a substance that was first obtained by processing the bark of the cinchona tree, a South American native plant that has been used as a fever reducer by Native Americans for centuries. This substance has been used historically to treat malaria, along with some other medical conditions, and although a number of antimalarial drugs are on the market today, it is still used in some regions. It is also used commercially as an additive to tonic water, a soft drink that is used as a mixer for other drinks in addition to being consumed straight.
Nature Quinine is a natural white crystalline alkaloid having antipyretic (fever-reducing), antimalarial, analgesic (painkilling), anti-inflammatory properties and a bitter taste. It is a stereoisomer of quinidine which, unlike Nature Quinine, is an anti-arrhythmic. Sulphate Quinine contains two major fused-ring systems: the aromatic quinoline and the bicyclic quinuclidine.
Though it has been synthesized in the lab, the bark of the cinchona tree is the only known natural source of Nature Quinine. The medicinal properties of the cinchona tree were originally discovered by the Quechua Indians of Peru and Bolivia; later, the Jesuits were the first to bring the cinchona to Europe.
Specification of Quinine HCL
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Items |
Specifications |
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Appearance |
White or almost white or colourless, fine, silky needles, often in clusters |
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Solubility |
Soluble in water, freely soluble in ethanol (96%). |
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Identification |
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A) TLC |
The principal spot in the chromatogram obtained with the test solution is similar in position, colour and size to the principal spot in the chromatogram obtained with the reference solution. |
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B) Bromine and ammonia |
A green colour develops when treated with bromine water and dilute ammonia |
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C) Fluorescence |
When examined in ultraviolet light at 366 nm,an intense blue fluorescence appears which disappears almost completely on the addition of 1 ml of HCL |
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D) Characteristic of chlorides |
It gives the reactions of chlorides |
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E) Test for pH |
Should comply |
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Appearance of solution |
Solution S is clear and not more intensely coloured than reference solution GY6 |
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pH |
6.0~6.8 |
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Specific optical rotation |
-245° ~ -258° |
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Other cinchona alkaloids Impurity C Any impurity eluted before quinine Any other impurity |
NMT 10% NMT 5%
NMT 2.5% |
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Sulphates |
NMT 500ppm |
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Barium |
Should comply |
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Loss on drying |
6%~10% |
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Sulphated ash |
NMT 0.1% |
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Assay |
99.0 %-101.0 % on dried substance |
Application of Quinine HCL
1. Quinine Hydrochloride is used as an antimalarial drug, and it is an active ingredient in extracts of the cinchona that have been used for that purpose since before 1633.
2. Quinine Hydrochloride is also a mild antipyretic and analgesic and has been used in common cold preparations for that purpose.
3. Quinine Hydrochloride used commonly as a bitter and flavoring agent, and it is still useful for the treatment of babesiosis. emeraldgo(at)hotmail.com.
4. Quinine Hydrochloride is also useful in some muscular disorders, especially nocturnal leg cramps and myotonia congenita, because of its direct effects on muscle membrane and sodium channels. The mechanisms of its antimalarial effects are not well understood.
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