Keywords

• Pitavastatin calcium
• Pitavastatin Calcium powder
• 147526-32-7

Quick Details

• ProName: Bulk Powder Pitavastatin calcium CAS N...
• CasNo: 147526-32-7
• Molecular Formula: C50H46CaF2N2O8
• Appearance: Fine Powder
• Application: API
• DeliveryTime: 3-5working days
• PackAge: 1kg/foil bag,25kgs/drum
• Port: QingDao,Shanghai,Tianjin
• ProductionCapacity: 5000 Metric Ton/Day
• Purity: 99%
• Storage: Keep in cool & dry place. Keep away fr...
• Transportation: Door to door courier.By air or sea.
• LimitNum: 10 Gram
• Moisture Content: <0.01
• Impurity: 0.001%

Superiority

Pitavastatin, launched for the treatment of hypercholesterolemia, belongs to the family of second-generation statins, also referred to as superstatins due to their improved efficacy as cholesterol lowering agents. Like other statins, pitavastatin reduces plasma cholesterol levels by competitively inhibiting HMG-CoA reductase, the rate-limiting enzyme of cholesterol biosynthesis in the liver. It is a more potent inhibitor of HMG-CoA reductase than the previously marketed statins and has the potential benefit of not undergoing significant metabolism by CYP3A4. Pitavastatin is synthesized in a multi-step sequence, including the key step of introducing the dihydroxyheptenoate side chain by cross-coupling of a 3-iodoquinoline intermediate with an alkenylborane reagent. Unlike rosuvastatin, pitavastatin has a high oral bioavailability (～80%). Plasma protein binding is also high for pitavastatin (＞95%), and regardless of the dosing, the highest tissue levels are found in the liver, its target organ. After oral administration, the peak plasma concentration is reached at ,0.8 h and the mean elimination half-life is ～11 h. Pitavastatin is only minimally metabolized, mainly by CYP2C8 and CYP2C9, and the predominant route of elimination of the parent drug and its metabolites is by means of bile excretion followed by elimination in the feces. In clinical studies, oral doses of 2–4 mg/day of pitavastatin produced dose-dependent reduction in LDL-cholesterol levels by 40–48% from baseline in patients with heterozygous familial hypercholesterolemia. In a 12-week double-blind comparative study, pitavastatin (2 mg/day) was more effective than pravastatin (10 mg/day) in reducing LDL-cholesterol levels (38 and 18%, respectively); however, both agents produced similar increases in HDL-cholesterol (～9%). The drug was well tolerated and the adverse reactions were mild and transient.

Details

Q1: Can i get some samples

A: Yes, we can supply the free sample, but the shipping cost be paid by our customers.

Q2: How to start orders or make payments 

A: Proforma invoice will be sent first after confirmation of order, enclosed our bank information. Payment by T/T, , Paypal or Escrow.

Q3: How to confirm the Product Quality before placing orders 

A:You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

Q4:What's your MOQ 

A:Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Q5: How about delivery lead time 

A:Delivery lead time: About 3-5 days after payment confirmed. (Chinese holiday not included)

Q6:Is it OK to print my logo on package

A:Sure.Please inform and offer your Logo formally before production.