(mk-677) is an orally active nonpeptide growth hormone (gh) secretagogue. ibutamoren mesylate (mk-0677) stimulates gh release through a pituitary and hypothalamic receptor that is different from the gh-releasing hormone receptor. mk-677is a drug which acts as a potent, orally active growth hormone secretagogue, mimicking the gh stimulating action of the endogenous hormone ghrelin. it has been demonstrated to increase the release of, and produces sustained increases in plasma levels of several hormones including growth hormone and igf-1, but without affecting cortisol levels. it is currently under development as a potential treatment for reduced levels of these hormones, such as in growth hormone deficient children or elderly adults, and human studies have shown it to increase both muscle mass and bone mineral density, making it a promising therapy for the treatment of frailty in the elderly. ibutamoren mesylate (mk-0677) also alters metabolism of body fat and so may have application in the treatment of obesity.

application

cholestyramine removes bile acids from the body by forming insoluble complexes with bile acids in the intestine, which are then excreted in the feces. as a result of this loss of bile acids, more plasma cholesterol is converted to bile acids in the liver to normalize levels. this conversion of cholesterol into bile acids lowers plasma cholesterol levels.

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