Incretin is a peptide hormone produced by gastrointestinal tract after meal, which can promote the secretion of insulin by islet β cells

It includes glucagon like peptide-1 (GLP-1) and Glucose dependent insulinotropic peptide (GIP), which are secreted by L cells in ileum and colon and K cells in duodenum, respectively. GLP-1 and GIP, as active hormones, can be released into the blood circulation within a few minutes after ingestion of food, but they will be rapidly degraded and inactivated by serine protease DPP-4.

The level of postprandial incretin in patients with type 2 diabetes mellitus is significantly lower, so preventing the inactivation of incretin to increase its action time will effectively reduce blood glucose.

As a DPP-4 inhibitor, agliptin benzoate can reduce the inactivation of GLP-1 in vivo by selectively inhibiting DPP-4, increase the level of GLP-1 in vivo, and reduce blood glucose. When the blood glucose is reduced to the normal level, it will not continue to play a hypoglycemic role, so it can effectively reduce the risk of hypoglycemia.

In addition, DPP-4 inhibitors can delay gastric emptying, increase satiety, inhibit appetite, and help patients reduce body weight.

Therefore, these drugs can effectively reduce blood glucose, but also reduce the risk of hypoglycemia and increased body weight, overcome the obstacles of patients' treatment, and bring new hope to the treatment of diabetes.

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